Efficacy of infliximab in psoriatic arthritis resistant to treatment with disease modifying antirheumatic drugs: an open pilot study.

Psoriatic arthritis (PsA) used to be considered a mild disease, but the development of erosive and deforming arthritis has been shown in a large proportion of patients. Disease modifying antirheumatic drugs (DMARDs) often do not achieve a satisfactory control of articular symptoms and there is no evidence of their effect on the progression of joint damage. Tumour necrosis factor α (TNFα) has a role in the pathogenesis of PsA, and there are some encouraging reports about the efficacy of TNFα neutralising agents for the treatment of the spondyloarthropathies, including PsA.